Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

被引：146

作者：

Kulkarni, Nalini H.

Onyia, Jude E.

Zeng, QingQiang

Tian, Xioayan

Liu, Min

Halladay, David L.

Frolik, Charles A.

Engler, Thomas

Wei, Tao

Kriauciunas, Aidas

Martin, T. John

Sato, Masahiko

Bryant, Henry U.

Ma, Yanfei L.

机构：

[1] Lilly Corp Ctr, Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

[2] Univ Utah, Div Radiobiol, Salt Lake City, UT USA

[3] St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 06期

关键词：

ovariectomy; glycogen synthase kinase-3 inhibitor; bone mass; C3H10T1/2; cells; Wnt; beta-catenin;

D O I：

10.1359/JBMR.060316

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

GSK-3, a component of the canonical Wnt signaling pathway, is implicated in regulation of bone mass. The effect of a small molecule GSK-3 inhibitor was evaluated in pre-osteoblasts and in osteopenic rats. GSK-3 inhibitor induced osteoblast differentiation in vitro and increased markers of bone formation in vitro and in vivo with concomitant increased bone mass and strength in rats.

引用

收藏

页码：910 / 920

页数：11

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