SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

被引：68

作者：

Shimizu, K ^{[1
]}

Okada, M ^{[1
]}

Takano, A ^{[1
]}

Nagai, K ^{[1
]}

机构：

[1] Osaka Univ, Inst Prot Res, Div Prot Metab, Suita, Osaka 5650871, Japan

来源：

FEBS LETTERS | 1999年 / 458卷 / 03期

关键词：

circadian rhythm; differential display; suprachiasmatic nucleus; leucine-rich repeat; protein phosphatase 2C; rat brain;

D O I：

10.1016/S0014-5793(99)01190-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN, SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN, (C) 1999 Federation of European Biochemical Societies.

引用

页码：363 / 369

页数：7

共 27 条

[1] A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light
Albrecht, U
Sun, ZS
Eichele, G
Lee, CC
[J]. CELL, 1997, 91 (07) : 1055 - 1064
[2] Closing the circadian loop:: CLOCK-induced transcription of its own inhibitors per and tim
Darlington, TK
Wager-Smith, K
Ceriani, MF
Staknis, D
Gekakis, N
Steeves, TDL
Weitz, CJ
Takahashi, JS
Kay, SA
[J]. SCIENCE, 1998, 280 (5369) : 1599 - 1603
[3] MUTATIONS OF THE ADENYLYL CYCLASE GENE THAT BLOCK RAS FUNCTION IN SACCHAROMYCES-CEREVISIAE
FIELD, J
XU, HP
MICHAELI, T
BALLESTER, R
SASS, P
WIGLER, M
COLICELLI, J
[J]. SCIENCE, 1990, 247 (4941) : 464 - 467
[4] Role of the CLOCK protein in the mammalian circadian mechanism
Gekakis, N
Staknis, D
Nguyen, HB
Davis, FC
Wilsbacher, LD
King, DP
Takahashi, JS
Weitz, CJ
[J]. SCIENCE, 1998, 280 (5369) : 1564 - 1569
[5] ISOLATION OF TIMELESS BY PER PROTEIN-INTERACTION - DEFECTIVE INTERACTION BETWEEN TIMELESS PROTEIN AND LONG-PERIOD MUTANT PER(L)
GEKAKIS, N
SAEZ, L
DELAHAYEBROWN, AM
MYERS, MP
SEHGAL, A
YOUNG, MW
WEITZ, CJ
[J]. SCIENCE, 1995, 270 (5237) : 811 - 815
[6] PLECKSTRIN HOMOLOGY DOMAINS BIND TO PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE
HARLAN, JE
HAJDUK, PJ
YOON, HS
FESIK, SW
[J]. NATURE, 1994, 371 (6493) : 168 - 170
[7] Signal transduction - Akt signaling: Linking membrane events to life and death decisions
Hemmings, BA
[J]. SCIENCE, 1997, 275 (5300) : 628 - 630
[8] SITE-DIRECTED MUTAGENESIS BY OVERLAP EXTENSION USING THE POLYMERASE CHAIN-REACTION
HO, SN
HUNT, HD
HORTON, RM
PULLEN, JK
PEASE, LR
[J]. GENE, 1989, 77 (01) : 51 - 59
[9] The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
Hogenesch, JB
Gu, YZ
Jain, SJ
Bradfield, CA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (10) : 5474 - 5479
[10] cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage
Ikeda, M
Nomura, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 233 (01) : 258 - 264

← 1 2 3 →