Incorporation of Antiangiogenic Therapies in the Treatment of Metastatic Breast Cancer

被引：9

作者：

Ademuyiwa, Foluso O. ^{[1
]}

Miller, Kathy D. ^{[1
]}

机构：

[1] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA

来源：

CLINICAL BREAST CANCER | 2008年 / 8卷

关键词：

Bevacizumab; Pazopanib; Tamoxifen; Tyrosine kinase inhibitors; Vascular endothelial growth factor;

D O I：

10.3816/CBC.2008.s.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis plays a central role in the development of metastasis in breast cancer. Recent results of large randomized trials show clinically significant improvements in outcomes with the use of bevacizumab in patients with metastatic breast cancer, leading to approval by European and US regulatory agencies. Several other antiangiogenic strategies are in various stages of development. This review discusses the results of recent clinical trials and novel mechanisms of inhibiting angiogenesis, resistance mechanisms, and toxicities; and raises key challenges that face optimal use and development of antiangiogenic agents in breast cancer.

引用

页码：S151 / S156

页数：6

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