Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)

被引：10

作者：

Ueki, N

Seki, N

Yano, K

Saito, T

Masuho, Y

Muramatsu, M

机构：

[1] Helix Res Inst, Chiba 2920812, Japan

[2] Kazusa DNA Res Inst, Chiba, Japan

[3] Natl Inst Radiol Sci, Genome Res Grp, Chiba 260, Japan

[4] Tokyo Med & Dent Univ, Med Res Inst, Dept Biol Cybernet, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 1999年 / 44卷 / 03期

关键词：

STAT3; PIAS3; cytokine; transcription factor; hematopoiesis; 1q21;

D O I：

10.1007/s100380050141

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mouse PIAS3 (protein inhibitor of activated STAT3) is a specific inhibitor of STAT3 that downregulates its signaling pathway. Here we report the isolation and chromosome mapping of the human PIAS3 gene. Human PIAS3 cDNA encoded a predicted protein of 619 aa which has 83% overall amino acid identity to the mouse counterpart. Based on polymerase chain reaction assisted analysis of a human/rodent mono-chromosomal hybrid cell panel and a radiation hybrid mapping panel, the human PIAS3 gene was mapped to the chromosome 1q21 region. Mapping of a crucial gene in modulating the STAT-3 signaling pathway may provide new clues to the understanding of malignancies or genetic disorders caused by this chromosome region.

引用

页码：193 / 196

页数：4

共 14 条

[1] MOLECULAR-CLONING OF APRF, A NOVEL IFN-STIMULATED GENE FACTOR-3 P91-RELATED TRANSCRIPTION FACTOR INVOLVED IN THE GP130-MEDIATED SIGNALING PATHWAY [J].