A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

被引：124

作者：

Chae, Pil Seok ^{[1
]}

Rasmussen, Soren G. F. ^{[3
]}

Rana, Rohini R. ^{[4
]}

Gotfryd, Kamil ^{[5
]}

Kruse, Andrew C. ^{[3
]}

Manglik, Aashish ^{[3
]}

Cho, Kyung Ho ^{[1
]}

Nurva, Shailika ^{[6
]}

Gether, Ulrik ^{[5
]}

Guan, Lan ^{[6
]}

Loland, Claus J. ^{[5
]}

Byrne, Bernadette ^{[4
]}

Kobilka, Brian K. ^{[3
]}

Gellman, Samuel H. ^{[2
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[3] Stanford Univ, Stanford, CA 94305 USA

[4] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

[5] Univ Copenhagen, Dept Neurosci & Pharmacol, DK-2200 Copenhagen, Denmark

[6] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Physiol & Mol Biophys, Lubbock, TX 79430 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 31期

基金：

新加坡国家研究基金会;

关键词：

amphiphiles; membrane proteins; molecular design; solubilization; stabilization; MUSCARINIC ACETYLCHOLINE-RECEPTOR; FACIAL AMPHIPHILES; AQUEOUS-SOLUTIONS; HEMIFLUORINATED SURFACTANTS; BETA(2) ADRENOCEPTOR; STRUCTURAL INSIGHTS; DETERGENT; CHOLESTEROL; AMPHIPOLS; COMPLEX;

D O I：

10.1002/chem.201200069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：9485 / 9490

页数：6

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