Serum- and Glucocorticoid-Regulated Kinase 1 Is Required for Nuclear Export of the Ribonucleoprotein of Influenza A Virus

被引：20

作者：

Alamares-Sapuay, Judith G. ^{[1
]}

Martinez-Gil, Luis ^{[1
]}

Stertz, Silke ^{[1
,2
]}

Miller, Matthew S. ^{[1
]}

Shaw, Megan L. ^{[1
]}

Palese, Peter ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY USA

[2] Univ Zurich, Inst Med Virol, Zurich, Switzerland

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 10期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

NF-KAPPA-B; INDUCIBLE KINASE; PROTEIN-KINASE; M1; PROTEIN; SGK1; PHOSPHORYLATION; INHIBITION; EXPRESSION; ASSOCIATION; PROPAGATION;

D O I：

10.1128/JVI.01258-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We previously performed a small interfering RNA (siRNA) screen and identified serum-and glucocorticoid-regulated kinase 1 (SGK1) as a host factor required for influenza A virus replication. However, the role of SGK1 in the influenza viral life cycle has never been examined. In this study, we demonstrate that SGK1 is required for optimal replication of influenza virus, using the SGK1 inhibitor GSK 650394 and SGK1-specific siRNAs. We also demonstrate that SGK1 is required for viral ribonucleoprotein nuclear export.

引用

页码：6020 / 6026

页数：7

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