Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media

被引：11

作者：

Bogaert, D

Holmlund, E

Lahdenkari, M

de Groot, R

Kilpi, T

Hermans, PWM ^{[1
]}

Kayhty, H

机构：

[1] Erasmus MC Sophia, Pediat Lab, Rotterdam, Netherlands

[2] Natl Publ Hlth Inst, Helsinki, Finland

[3] Univ Med Ctr St Radboud, Lab Pediat Infect Dis, Nijmegen, Netherlands

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2006年 / 46卷 / 02期

关键词：

Streptococcus pneumoniae; PpmA; acute otitis media;

D O I：

10.1111/j.1574-695X.2005.00012.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).

引用

页码：166 / 168

页数：3

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