Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- β1 as compared with healthy nasal mucosa

被引：20

作者：

Balsalobre, Leonardo ^{[1
]}

Pezato, Rogerio ^{[1
,2
]}

Perez-Novo, Claudina ^{[2
]}

Alves, Maria Teresa S. ^{[3
]}

Santos, Rodrigo P. ^{[1
]}

Bachert, Claus ^{[2
]}

Weckx, Luc L. M. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Otolaryngol Head & Neck Surg, Sao Paulo, Brazil

[2] Univ Ghent, Ghent Univ Hosp, Dept Otorhinolaryngol, Upper Airway Res Lab, B-9000 Ghent, Belgium

[3] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil

来源：

JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY | 2013年 / 42卷

关键词：

TGF-beta; 1; Nasal polyps; Rhinosinusitis; Mucosa; GROWTH-FACTOR-BETA; UPPER AIRWAYS; DISEASE; TRANSFORMING-GROWTH-FACTOR-BETA-1; RHINOSINUSITIS; PATHOGENESIS; FIBROBLASTS; TGF-BETA-1; CYTOKINES;

D O I：

10.1186/1916-0216-42-29

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software. Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05). Conclusion: The lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.

引用

页数：5

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