First synthesis of 10α-(trifluoromethyl)deoxoartemisinin

被引：22

作者：

Chorki, F

Grellepois, F

Crousse, B

Hoang, VD

Van Hung, N

Bonnet-Delpon, D

Bégué, JP

机构：

[1] Ctr Etud Pharmaceut, BioCIS, F-92296 Chatenay Malabry, France

[2] CNST, Inst Chem, Hanoi, Vietnam

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 05期

关键词：

D O I：

10.1021/ol017227z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel, nonacetal (trifluoromethyl)deoxoartemisinin was prepared with good stereoselectivity. This compound was obtained by debromination of the 10alpha-CF3-10-bromodeoxoartemisinin in the presence of tributyltin hydride at reflux in toluene without alteration of the endoperoxide bridge. It presented a reasonable antimalarial activity.

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收藏

页码：757 / 759

页数：3

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