Randomized controlled phase II trial of glatiramer acetate in ALS

被引：42

作者：

Gordon, PH

Doorish, C

Montes, J

Mosely, RL

Diamond, B

MacArthur, RB

Weimer, LH

Kaufmann, P

Hays, AP

Rowland, LP

Gendelman, HE

Przedborski, S

Mitsumoto, H

机构：

[1] Columbia Univ, Dept Neurol, Gen Clin Res Ctr, New York, NY 10027 USA

[2] Columbia Univ, Dept Pharmacol, Gen Clin Res Ctr, New York, NY 10027 USA

[3] Columbia Univ, Dept Pathol, Gen Clin Res Ctr, New York, NY 10027 USA

[4] Columbia Univ, Dept Biostat, Gen Clin Res Ctr, New York, NY 10027 USA

[5] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Ctr Neurovirol & Neurodegenerat Disorders, Omaha, NE USA

来源：

NEUROLOGY | 2006年 / 66卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000204235.81272.e2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors conducted a randomized controlled trial to test the safety and immunology of glatiramer acetate in ALS. Twenty treated patients were randomly assigned to daily or biweekly injections. Ten control patients were selected from another trial and followed up concurrently. Injection reactions were the only common adverse event (p = 0.01). Treated patients showed enhanced lymphocyte proliferation (p = 0.02). The safety profile and immune effects support conducting larger trials of dose selection and efficacy.

引用

页码：1117 / 1119

页数：3

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