DIVERGE: phylogeny-based analysis for functional-structural divergence of a protein family

被引：245

作者：

Gu, X ^{[1
]}

Vander Velden, K ^{[1
]}

机构：

[1] Iowa State Univ, Dept Zool & Genet, Program Bioinformat & Computat Biol, Ames, IA 50011 USA

来源：

BIOINFORMATICS | 2002年 / 18卷 / 03期

关键词：

D O I：

10.1093/bioinformatics/18.3.500

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Detecting Variability in Evolutionary Rates among GEnes (DIVERGE) is a software system to study functional divergence of a protein family by detecting site-specific change in evolutionary rate using a multiple alignment of amino acid sequences for a given phylogenetic tree. The program first conducts a statistical test for site-specific rate shifts along the tree, and predicting candidate amino acid residues responsible for functional divergence based on posterior analysis. These results can then be mapped on the 3D protein structure if available.

引用

页码：500 / 501

页数：2

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