Enantioselective methylation of the lithium enolate of 1-tetralone mediated by chiral C-2-symmetric DMEU derivatives

被引：8

作者：

Ishii, K ^{[1
]}

Aoki, S ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(96)02372-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral C-2-symmetric DMEU derivatives were designed and synthesized as chiral ligands for lithium. The reaction of the lithium enolate (2) of 1-tetralone (1) with methyl iodide in toluene in the presence of a DMEU derivative (11) and hexamethyldisilazane gave (S)-2-methyl-1-tetralone ((S)-3) in up to 92% ee. (C) 1997, Elsevier Science Ltd. All rights reserved.

引用

页码：563 / 566

页数：4

共 11 条

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