Physiology and pathophysiology of the interstitial cell of Cajal: From bench to bedside - III. Interaction of interstitial cells of Cajal with neuromediators: an interim assessment

被引：29

作者：

Daniel, EE ^{[1
]}

机构：

[1] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2001年 / 281卷 / 06期

关键词：

intestinal pacemaking; intestinal neurotransmission; nitric oxide; acetylcholine; substance P;

D O I：

10.1152/ajpgi.2001.281.6.G1329

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Interstitial cells of Cajal (ICC) control gastrointestinal motility; some pace slow waves and others act in enteric neurotransmission. This review asks the question, does either class of ICC receive and respond to messages carried by neuromediators from these nerves? Relevant evidence includes the presence of receptors or responses to exogenous neuromediators and responses to endogenous neuromediators. Some pacemaking ICC networks have receptors for or respond to some exogenous neuromediators. None is known to respond to endogenous neuromediators. Intramuscular ICC have receptors for and respond to some neuromediators and are required in mice for responses to the exogenous and endogenous neuromediators nitric oxide and acetylcholine. The mechanisms underlying this requirement remain unclear. ICC pathologies exist, but their origins are unknown.

引用

页码：G1329 / G1332

页数：4

共 29 条

[1]

Daniel EE, 1999, NEUROGASTROENT MOTIL, V11, P375

[2]

Daniel EE, 2000, NEUROGASTROENT MOTIL, V12, P317

[3] Interstitial cells of Cajal direct normal propulsive contractile activity in the mouse small intestine [J].

Der-Silaphet, T ;

Malysz, J ;

Hagel, S ;

Arsenault, AL ;

Huizinga, JD .

GASTROENTEROLOGY, 1998, 114 (04) :724-736

[4] Vagal inhibition in the antral region of guinea pig stomach [J].

Dickens, EJ ;

Edwards, FR ;

Hirst, GDS .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 279 (02) :G388-G399

[5] Molecular markers expressed in cultured and freshly isolated interstitial cells of Cajal [J].

Epperson, A ;

Hatton, WJ ;

Callaghan, B ;

Doherty, P ;

Walker, RL ;

Sanders, KM ;

Ward, SM ;

Horowitz, B .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2000, 279 (02) :C529-C539

[6] Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract [J].

Grady, EF ;

Baluk, P ;

Bohm, S ;

Gamp, PD ;

Wong, H ;

Payan, DG ;

Ansel, J ;

Portbury, AL ;

Furness, JB ;

McDonald, DM ;

Bunnett, NW .

JOURNAL OF NEUROSCIENCE, 1996, 16 (21) :6975-6986

[7]

Huizinga JD, 1998, AM J PHYSIOL-GASTR L, V275, pG381, DOI 10.1152/ajpgi.1998.275.3.G381

[8] Co-operation between neural and myogenic mechanisms in the control of distension-induced peristalsis in the mouse small intestine [J].

Huizinga, JD ;

Ambrous, K ;

Der-Silaphet, T .

JOURNAL OF PHYSIOLOGY-LONDON, 1998, 506 (03) :843-856

[9] Basal release of nitric oxide induces an oscillatory motor pattern in canine colon [J].

Keef, KD ;

Murray, DC ;

Sanders, KM ;

Smith, TK .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 499 (03) :773-786

[10] Regulation of pacemaker currents in interstitial cells of Cajal from murine small intestine by cyclic nucleotides [J].

Koh, XD ;

Kim, TW ;

Jun, JY ;

Glasgow, NJ ;

Ward, SM ;

Sanders, KM .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 527 (01) :149-162

← 1 2 3 →