The effect of botulinum toxin A on gastrocnemius length: magnitude and duration of response

被引:106
作者
Eames, NWA
Baker, R
Hill, N
Graham, K
Taylor, T
Cosgrove, A
机构
[1] Queens Univ Belfast, Musgrave Pk Hosp, Gait Anal Lab, Belfast BT9 7JB, Antrim, North Ireland
[2] Royal Belfast Hosp Sick Children, Belfast, Antrim, North Ireland
[3] Royal Childrens Hosp, Melbourne, Vic, Australia
关键词
D O I
10.1017/S0012162299000493
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Thirty-nine ambulant children (22 with hemiplegia, lr with diplegia) with spastic cerebral palsy receiving isolated gastrocnemius muscle injection with botulinum toxin A mere studied prospectively. The children had a mean age of 6 years (range 3 to 13 years). Measurement of gastrocnemius muscle length was used to estimate the dynamic component of each child's spasticity and to quantify the response. There was a strong correlation between the dynamic component of spasticity before injection and the corresponding magnitude of the response after injection. Children undergoing repeated injections showed similar correlations. A strong correlation was found between the duration of response and the dynamic component. Children with hemiplegia showed twice the duration for a given dynamic component compared with those with diplegia when injected with the same total dose per unit body weight. Long-term lengthening did not occur for the cohort, although some patients showed a response at a 12-month follow-up. By delaying shortening, the injections may have a role in delaying the need for surgery. Injections were well tolerated with few side effects.
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页码:226 / 232
页数:7
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