Use of Direct Thrombin Inhibitor for Treatment of Cerebral Venous Thrombosis

被引:20
作者
Hon, Sonny Fong Kwong [1 ]
Li, Ho Lun Terrance [1 ]
Cheng, Pui Wai [1 ]
机构
[1] Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
关键词
Anticoagulation; cerebral venous thrombosis; dabigatran; Pradaxa; sinus vein thrombosis; warfarin; young stroke; SINUS THROMBOSIS; ATRIAL-FIBRILLATION; DABIGATRAN; HEPARIN;
D O I
10.1016/j.jstrokecerebrovasdis.2012.02.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cerebral venous thrombosis is an uncommon condition with difficulties in diagnosis and treatment. There is limited study on the best treatment option for this disease. The mainstay of treatment remains systemic anticoagulation with a lengthy duration of warfarin, which has a troublesome unpredictable drug effect, various drug and food interactions, and an increased risk of bleeding. Recent availability of direct thrombin inhibitor provides an alternative option of systemic anticoagulation in various thromboembolism conditions. We report 2 cases of cerebral venous thrombosis treated with a direct thrombin inhibitor with good clinical and radiologic results.
引用
收藏
页码:915.e11 / 915.e15
页数:5
相关论文
共 12 条
[1]   Cerebral venous thrombosis: an update [J].
Bousser, Marie-Germaine ;
Ferro, Jose M. .
LANCET NEUROLOGY, 2007, 6 (02) :162-170
[2]   Dabigatran versus Warfarin in Patients with Atrial Fibrillation. [J].
Connolly, Stuart J. ;
Ezekowitz, Michael D. ;
Yusuf, Salim ;
Eikelboom, John ;
Oldgren, Jonas ;
Parekh, Amit ;
Pogue, Janice ;
Reilly, Paul A. ;
Themeles, Ellison ;
Varrone, Jeanne ;
Wang, Susan ;
Alings, Marco ;
Xavier, Denis ;
Zhu, Jun ;
Diaz, Rafael ;
Lewis, Basil S. ;
Darius, Harald ;
Diener, Hans-Christoph ;
Joyner, Campbell D. ;
Wallentin, Lars .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) :1139-1151
[3]   Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis [J].
de Bruijn, SFTM ;
Stam, J .
STROKE, 1999, 30 (03) :484-488
[4]   HEPARIN TREATMENT IN SINUS VENOUS THROMBOSIS [J].
EINHAUPL, KM ;
VILLRINGER, A ;
MEISTER, W ;
MEHRAEIN, S ;
GARNER, C ;
PELLKOFER, M ;
HABERL, RL ;
PFISTER, HW ;
SCHMIEDEK, P .
LANCET, 1991, 338 (8767) :597-600
[5]   Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism [J].
Eriksson, Bengt I. ;
Quinlan, Daniel J. ;
Eikelboom, John W. .
ANNUAL REVIEW OF MEDICINE, VOL 62, 2011, 2011, 62 :41-57
[6]   Barriers to the use of anticoagulation for nonvalvular atrial fibrillation - A representative survey of Australian family physicians [J].
Gattellari, Melina ;
Worthington, John ;
Zwar, Nicholas ;
Middleton, Sandy .
STROKE, 2008, 39 (01) :227-230
[7]   Cerebral venous sinus thrombosis [J].
Kimber, J .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2002, 95 (03) :137-142
[8]  
Sacco RL, 2006, STROKE, V37, P577, DOI 10.1161/01.STR.0000199147.30016.74
[9]   Diagnosis and Management of Cerebral Venous Thrombosis A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association [J].
Saposnik, Gustavo ;
Barinagarrementeria, Fernando ;
Brown, Robert D., Jr. ;
Bushnell, Cheryl D. ;
Cucchiara, Brett ;
Cushman, Mary ;
deVeber, Gabrielle ;
Ferro, Jose M. ;
Tsai, Fong Y. .
STROKE, 2011, 42 (04) :1158-1192
[10]   Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement [J].
Stangier, J ;
Eriksson, BI ;
Dahl, OE ;
Ahnfelt, L ;
Nehmiz, G ;
Stähle, H ;
Rathgen, K ;
Svärd, R .
JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 45 (05) :555-563