Reductive activation of nitroheterocyclic compounds

被引：101

作者：

Tocher, JH

机构：

[1] Chemotherapy Research Unit, University of East London

来源：

GENERAL PHARMACOLOGY | 1997年 / 28卷 / 04期

关键词：

nitroaromatic compounds; reductive activation; reactive intermediates; mode of action; DNA damage;

D O I：

10.1016/S0306-3623(96)00283-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Nitroaromatic compounds are important chemotherapy agents. 2. Their selective toxicity is determined by reduction to the biologically active form in the absence of oxygen. 3. Nitroaromatics are extensively used in the treatment of anaerobic infections and to target hypoxic tumor cells in cancer therapy. 4. Possible mutagenic action is related to the relative ease of nitro group reduction. 5. The mode of action and clinical application of nitroaromatic compounds is summarized. (C) 1997 Elsevier Science Inc.

引用

页码：485 / 487

页数：3

共 27 条

[1] THE NOVEL FLUORINATED 2-NITROIMIDAZOLE HYPOXIA PROBE SR-4554 - REDUCTIVE METABOLISM AND SEMIQUANTITATIVE LOCALIZATION IN HUMAN OVARIAN-CANCER MULTICELLULAR SPHEROIDS AS MEASURED BY ELECTRON-ENERGY-LOSS SPECTROSCOPIC ANALYSIS [J].

ABOAGYE, EO ;

LEWIS, AD ;

JOHNSON, A ;

WORKMAN, P ;

TRACY, M ;

HUXHAM, IM .

BRITISH JOURNAL OF CANCER, 1995, 72 (02) :312-318

[2] REDOX, RADIATION, AND REDUCTIVE BIOACTIVATION [J].

ADAMS, GE .

RADIATION RESEARCH, 1992, 132 (02) :129-139

[3] BIOREDUCTIVE DRUGS FOR CANCER-THERAPY - THE SEARCH FOR TUMOR SPECIFICITY [J].

ADAMS, GE ;

STRATFORD, IJ .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 29 (02) :231-238

[4] HYPOXIA-MEDIATED NITRO-HETEROCYCLIC DRUGS IN THE RADIOTHERAPY AND CHEMOTHERAPY OF CANCER - AN OVERVIEW [J].

ADAMS, GE ;

STRATFORD, IJ .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :71-76

[5] STRUCTURE ACTIVITY RELATIONSHIP OF MUTAGENIC AROMATIC AND HETEROAROMATIC NITRO-COMPOUNDS - CORRELATION WITH MOLECULAR-ORBITAL ENERGIES AND HYDROPHOBICITY [J].

DEBNATH, AK ;

DECOMPADRE, RLL ;

DEBNATH, G ;

SHUSTERMAN, AJ ;

HANSCH, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :786-797

[6] A REVIEW OF HYPOXIC CELL RADIOSENSITIZATION [J].

DISCHE, S .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 20 (01) :147-152

[7] STRUCTURE-CYTOTOXICITY RELATIONSHIPS OF NITROIMIDAZOLES IN AN INVITRO SYSTEM [J].

EDWARDS, DI ;

KNOX, RJ ;

KNIGHT, RC .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :791-793

[8] NITROIMIDAZOLE DRUGS - ACTION AND RESISTANCE MECHANISMS .2. MECHANISMS OF RESISTANCE [J].

EDWARDS, DI .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 31 (02) :201-210

[9] REDUCTION OF NITROIMIDAZOLES INVITRO AND DNA DAMAGE [J].

EDWARDS, DI .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :53-58

[10] NITROIMIDAZOLE DRUGS - ACTION AND RESISTANCE MECHANISMS .1. MECHANISMS OF ACTION [J].

EDWARDS, DI .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 31 (01) :9-20

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