The distribution of fatty acid ethyl esters among lipoproteins and albumin in human serum

被引：19

作者：

Bird, DA

Kabakibi, A

Laposata, M

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT PATHOL,DIV CLIN LABS,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BOSTON,MA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1997年 / 21卷 / 04期

关键词：

lipids; ethanol; fatty acids; FAEE; lipoprotein;

D O I：

10.1111/j.1530-0277.1997.tb03809.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Fatty acid ethyl esters (FAEEs) are nonoxidative products of ethanol metabolism and have been implicated as mediators of ethanol-induced organ damage, Previous studies have demonstrated that FAEEs bind to lipoproteins and albumin in human plasma after ethanol ingestion. Analysis of human serum with varying blood ethanol levels and endogenously formed FAEEs revealed a positive correlation between serum FAEE concentration and the percentage of FAEEs associated with lipoproteins, predominantly very low density and low density lipoprotein. Similar results were obtained when increasing amounts of FAEEs were added to serum with zero blood ethanol. Additional studies indicated that free fatty acids and FAEEs do not compete for binding to albumin or lipoproteins. Data support the conclusion that the distribution of FAEEs among their carriers in the serum is dependent on serum FAEE concentration.

引用

页码：602 / 605

页数：4

共 14 条

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ABIDI SA, 1992, MED NUTR COMPLICATIO, P45

[2] Purification of fatty acid ethyl esters by solid-phase extraction and high-performance liquid chromatography [J].