Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome

被引：40

作者：

Chen, Shih-Pin ^{[1
,2
,3
]}

Chung, Yu-Ting ^{[4
,5
]}

Liu, Tsung-Yun ^{[4
,5
,6
]}

Wang, Yen-Feng ^{[1
,2
,3
]}

Fuh, Jong-Ling ^{[1
,2
,3
,7
]}

Wang, Shuu-Jiun ^{[1
,2
,3
,7
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Neurol, Neurol Inst, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Environm & Occupat Hlth Sci, Sch Med, Taipei 112, Taiwan

[5] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Dept & Inst Pharmacol, Sch Med, Taipei 112, Taiwan

[7] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2013年 / 61卷

关键词：

Reversible cerebral vasoconstriction syndrome; Thunderclap headaches; 8-Iso-prostaglandin F-2 alpha; Endothelial dysfunction; Oxidative stress; ANEURYSMAL SUBARACHNOID HEMORRHAGE; THROMBOXANE A(2) RECEPTOR; 8-ISO-PROSTAGLANDIN F2-ALPHA; F-2-ISOPROSTANES; ACTIVATION; ISOPROSTANES; ADHESION; LINK;

D O I：

10.1016/j.freeradbiomed.2013.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The pathophysiology of reversible cerebral vasoconstriction syndrome (RCVS) is unknown. Oxidative stress is detrimental to endothelial function and vascular reactivity. We hypothesized that the oxidative stress marker 8-iso-prostaglandin F-2 alpha, which is also a potent vasoconstrictor, might contribute to the pathogenesis of RCVS. Recruited participants included 103 RCVS patients, 53 patients with primary headache with acute severe attacks, and 54 healthy controls. Subjects recruited prior to 2009 were discovery cohort, whereas those after 2009, replication cohort. Urine samples were obtained from all patients at registration and from 79 patients with RCVS again at remission stage. Urine 8-iso-prostaglandin F-2 alpha was analyzed by liquid chromatography-tandem mass spectrometry. Patients with RCVS received magnetic resonance angiography and transcranial color-coded sonography. In RCVS patients, the urine 8-iso-prostaglandin F-2 alpha level was higher than that in the other groups in discovery, replication, and combined cohorts (RCVS, 0.29 +/- 0.18; primary headache with acute severe attacks, 0.21 +/- 0.19; control, 0.18 +/- 0.09 ng/mg creatinine; P < 0.001), and it was positively correlated with the flow velocities of major intracranial arteries, especially within the first week of disease onset (middle cerebral artery, Spearman's correlation coefficient [r(s)] = 0.580, P=0.002; anterior cerebral artery, r(s)=0.472, P=0.042; posterior cerebral artery, r(s)=0.457, P=0.022; basilar artery, r(s)= 0.530, P=0.002). The 8-iso-prostaglandin F-2 alpha, level decreased from the ictalto remission stage in RCVS patients (0.31 +/- 0.21 vs 0.16 +/- 0.10 ng/mg creatinine, P < 0.001). 8-Iso-prostaglandin F-2 alpha was higher in patients with RCVS and correlated with the severity of vasoconstrictions. Further studies are required to explore its potential pathogenic role. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：243 / 248

页数：6

共 33 条

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Oxidative Stress Changes in Pregnant Patients With and Without Severe Preeclampsia [J].