共 42 条
Attacking pathogens through their hosts
被引:26
作者:

Kellam, P
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Div Infect & Immun, Virus Genom & Bioinformat Grp, London W1T 4JF, England UCL, Div Infect & Immun, Virus Genom & Bioinformat Grp, London W1T 4JF, England
机构:
[1] UCL, Div Infect & Immun, Virus Genom & Bioinformat Grp, London W1T 4JF, England
关键词:
D O I:
10.1186/gb-2006-7-1-201
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Through understanding the intricacies of host-pathogen interactions, it is now possible to inhibit the growth of microbes, especially viruses, by targeting host-cell proteins and functions. This new antimicrobial strategy has proved effective in the laboratory and in the clinic, and it has great potential for the future.
引用
收藏
页数:8
相关论文
共 42 条
[1]
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
[J].
Berns, K
;
Hijmans, EM
;
Mullenders, J
;
Brummelkamp, TR
;
Velds, A
;
Heimerikx, M
;
Kerkhoven, RM
;
Madiredjo, M
;
Nijkamp, W
;
Weigelt, B
;
Agami, R
;
Ge, W
;
Cavet, G
;
Linsley, PS
;
Beijersbergen, RL
;
Bernards, R
.
NATURE,
2004, 428 (6981)
:431-437

Berns, K
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Hijmans, EM
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Mullenders, J
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Brummelkamp, TR
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Velds, A
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Heimerikx, M
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Kerkhoven, RM
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Madiredjo, M
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Nijkamp, W
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Weigelt, B
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Agami, R
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Ge, W
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Cavet, G
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Linsley, PS
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Beijersbergen, RL
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

Bernards, R
论文数: 0 引用数: 0
h-index: 0
机构: Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands
[2]
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
[J].
Bordier, BB
;
Ohkanda, J
;
Liu, P
;
Lee, SY
;
Salazar, FH
;
Marion, PL
;
Ohashi, K
;
Meuse, L
;
Kay, MA
;
Casey, JL
;
Sebti, SM
;
Hamilton, AD
;
Glenn, JS
.
JOURNAL OF CLINICAL INVESTIGATION,
2003, 112 (03)
:407-414

Bordier, BB
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Ohkanda, J
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Liu, P
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Lee, SY
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Salazar, FH
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Marion, PL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Ohashi, K
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Meuse, L
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Kay, MA
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Casey, JL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Sebti, SM
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Hamilton, AD
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

Glenn, JS
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA
[3]
A prenylation inhibitor prevents production of infectious hepatitis delta virus particles
[J].
Bordier, BB
;
Marion, PL
;
Ohashi, K
;
Kay, MA
;
Greenberg, HB
;
Casey, JL
;
Glenn, JS
.
JOURNAL OF VIROLOGY,
2002, 76 (20)
:10465-10472

Bordier, BB
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Marion, PL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Ohashi, K
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Kay, MA
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Greenberg, HB
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Casey, JL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Glenn, JS
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA
[4]
A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
[J].
Boyce, M
;
Bryant, KF
;
Jousse, C
;
Long, K
;
Harding, HP
;
Scheuner, D
;
Kaufman, RJ
;
Ma, DW
;
Coen, DM
;
Ron, D
;
Yuan, JY
.
SCIENCE,
2005, 307 (5711)
:935-939

Boyce, M
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Bryant, KF
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Jousse, C
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Long, K
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Harding, HP
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Scheuner, D
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Kaufman, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Ma, DW
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Coen, DM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Ron, D
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Yuan, JY
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[5]
Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
[J].
Davis, GL
;
Esteban-Mur, R
;
Rustgi, V
;
Hoefs, J
;
Gordon, SC
;
Trepo, C
;
Shiffman, ML
;
Zeuzem, S
;
Craxi, A
;
Ling, MH
;
Albrecht, J
.
NEW ENGLAND JOURNAL OF MEDICINE,
1998, 339 (21)
:1493-1499

Davis, GL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Esteban-Mur, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Rustgi, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Hoefs, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Gordon, SC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Trepo, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Shiffman, ML
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Zeuzem, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Craxi, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Ling, MH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA

Albrecht, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Coll Med, Sect Hepatobiliary Dis, Gainesville, FL 32610 USA
[6]
Strategies in the design of antiviral drugs
[J].
De Clercq, E
.
NATURE REVIEWS DRUG DISCOVERY,
2002, 1 (01)
:13-25

De Clercq, E
论文数: 0 引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
[7]
Statins inhibit HIV-1 infection by down-regulating Rho activity
[J].
del Real, G
;
Jiménez-Baranda, S
;
Mira, E
;
Lacalle, RA
;
Lucas, P
;
Gómez-Moutón, C
;
Alegret, M
;
Peña, JM
;
Rodríguez-Zapata, M
;
Alvarez-Mon, M
;
Martínez-A, C
;
Mañes, S
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2004, 200 (04)
:541-547

del Real, G
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Jiménez-Baranda, S
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Mira, E
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Lacalle, RA
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Lucas, P
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Gómez-Moutón, C
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Alegret, M
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Peña, JM
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Rodríguez-Zapata, M
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Alvarez-Mon, M
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Martínez-A, C
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

Mañes, S
论文数: 0 引用数: 0
h-index: 0
机构: CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain
[8]
The price of innovation: new estimates of drug development costs
[J].
DiMasi, JA
;
Hansen, RW
;
Grabowski, HG
.
JOURNAL OF HEALTH ECONOMICS,
2003, 22 (02)
:151-185

DiMasi, JA
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Tufts Ctr Study Drug Dev, Boston, MA 02111 USA

Hansen, RW
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Tufts Ctr Study Drug Dev, Boston, MA 02111 USA

Grabowski, HG
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, Tufts Ctr Study Drug Dev, Boston, MA 02111 USA
[9]
Identification of cell surface targets for HIV-1 therapeutics using genetic screens
[J].
Dunn, SJ
;
Khan, MH
;
Chan, UA
;
Scearce, RL
;
Melara, CL
;
Paul, AM
;
Sharma, V
;
Bih, FY
;
Holzmayer, TA
;
Luciw, PA
;
Abo, A
.
VIROLOGY,
2004, 321 (02)
:260-273

Dunn, SJ
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Khan, MH
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Chan, UA
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Scearce, RL
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Melara, CL
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Paul, AM
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Sharma, V
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Bih, FY
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Holzmayer, TA
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Luciw, PA
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA

Abo, A
论文数: 0 引用数: 0
h-index: 0
机构: PPD Discovery Inc, Menlo Pk, CA 94025 USA
[10]
Prenylation inhibitors: a novel class of antiviral agents
[J].
Einav, S
;
Glenn, JS
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
2003, 52 (06)
:883-886

Einav, S
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

Glenn, JS
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA