Attacking pathogens through their hosts

被引:26
作者
Kellam, P [1 ]
机构
[1] UCL, Div Infect & Immun, Virus Genom & Bioinformat Grp, London W1T 4JF, England
关键词
D O I
10.1186/gb-2006-7-1-201
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Through understanding the intricacies of host-pathogen interactions, it is now possible to inhibit the growth of microbes, especially viruses, by targeting host-cell proteins and functions. This new antimicrobial strategy has proved effective in the laboratory and in the clinic, and it has great potential for the future.
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页数:8
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共 42 条
[1]   A large-scale RNAi screen in human cells identifies new components of the p53 pathway [J].
Berns, K ;
Hijmans, EM ;
Mullenders, J ;
Brummelkamp, TR ;
Velds, A ;
Heimerikx, M ;
Kerkhoven, RM ;
Madiredjo, M ;
Nijkamp, W ;
Weigelt, B ;
Agami, R ;
Ge, W ;
Cavet, G ;
Linsley, PS ;
Beijersbergen, RL ;
Bernards, R .
NATURE, 2004, 428 (6981) :431-437
[2]   In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus [J].
Bordier, BB ;
Ohkanda, J ;
Liu, P ;
Lee, SY ;
Salazar, FH ;
Marion, PL ;
Ohashi, K ;
Meuse, L ;
Kay, MA ;
Casey, JL ;
Sebti, SM ;
Hamilton, AD ;
Glenn, JS .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (03) :407-414
[3]   A prenylation inhibitor prevents production of infectious hepatitis delta virus particles [J].
Bordier, BB ;
Marion, PL ;
Ohashi, K ;
Kay, MA ;
Greenberg, HB ;
Casey, JL ;
Glenn, JS .
JOURNAL OF VIROLOGY, 2002, 76 (20) :10465-10472
[4]   A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress [J].
Boyce, M ;
Bryant, KF ;
Jousse, C ;
Long, K ;
Harding, HP ;
Scheuner, D ;
Kaufman, RJ ;
Ma, DW ;
Coen, DM ;
Ron, D ;
Yuan, JY .
SCIENCE, 2005, 307 (5711) :935-939
[5]   Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C [J].
Davis, GL ;
Esteban-Mur, R ;
Rustgi, V ;
Hoefs, J ;
Gordon, SC ;
Trepo, C ;
Shiffman, ML ;
Zeuzem, S ;
Craxi, A ;
Ling, MH ;
Albrecht, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (21) :1493-1499
[6]   Strategies in the design of antiviral drugs [J].
De Clercq, E .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (01) :13-25
[7]   Statins inhibit HIV-1 infection by down-regulating Rho activity [J].
del Real, G ;
Jiménez-Baranda, S ;
Mira, E ;
Lacalle, RA ;
Lucas, P ;
Gómez-Moutón, C ;
Alegret, M ;
Peña, JM ;
Rodríguez-Zapata, M ;
Alvarez-Mon, M ;
Martínez-A, C ;
Mañes, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) :541-547
[8]   The price of innovation: new estimates of drug development costs [J].
DiMasi, JA ;
Hansen, RW ;
Grabowski, HG .
JOURNAL OF HEALTH ECONOMICS, 2003, 22 (02) :151-185
[9]   Identification of cell surface targets for HIV-1 therapeutics using genetic screens [J].
Dunn, SJ ;
Khan, MH ;
Chan, UA ;
Scearce, RL ;
Melara, CL ;
Paul, AM ;
Sharma, V ;
Bih, FY ;
Holzmayer, TA ;
Luciw, PA ;
Abo, A .
VIROLOGY, 2004, 321 (02) :260-273
[10]   Prenylation inhibitors: a novel class of antiviral agents [J].
Einav, S ;
Glenn, JS .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (06) :883-886