Expression of G-CSF and GM-CSF in human meningiomas correlates with increased tumor proliferation and vascularization

被引:45
作者
Braun, B
Lange, M
Oeckler, R
Mueller, MM
机构
[1] German Canc Res Ctr, Div Carcinogenesis & Differentiat, D-69120 Heidelberg, Germany
[2] Hosp Darmstadt, Dept Gastroenterol, Darmstadt, Germany
[3] Hosp Villingen Schwenningen, Dept Neurosurg, Villigen, Switzerland
关键词
G-CSF; GM-CSF; Ki-67; meningiomas; proliferation; tumor progression;
D O I
10.1023/B:NEON.0000027751.87894.f0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The hematopoietic growth factors granulocyte- and granulocyte- macrophage colony stimulating factor (G-CSF and GM-CSF) are nowadays widely used in routine cancer therapies as potent factors to control radiation and chemotherapy induced neutropenia, a side effect that frequently endangers the success of tumor therapies. However, there is little information about the role of G-CSF and GM-CSF for tumor growth or progression. We were interested in the expression and potential role of both factors in human meningiomas, tumors of arachnoidal origin that account for about 20% of all primary intracranial tumors. Therefore, we analyzed immunohistochemically the protein expression of G-CSF, GM-CSF and their respective receptors in 30 meningioma tissues of different malignancy and histopathological type. Both factors and receptors were not expressed in the corresponding normal tissue. In contrast, G-CSF, GM-CSF and their receptors were expressed to a varying degree in human meningiomas. Increasing expression of both factors and receptors correlated significantly with enhanced proliferation in the tumor and thus with higher malignancy. In addition, a strong perivascular expression of G-CSF was associated with a highly vascularized tumor type. Thus, expression of both G-CSF and GM-CSF is associated with the expression of proliferation vascularization, two markers of an increasingly malignant tumor phenotype, suggesting a contribution of both factors to tumor progression.
引用
收藏
页码:131 / 140
页数:10
相关论文
共 59 条
  • [1] GROWTH-FACTORS AND CANCER
    AARONSON, SA
    [J]. SCIENCE, 1991, 254 (5035) : 1146 - 1153
  • [2] [Anonymous], 1994, J CLIN ONCOL, V12, P2471
  • [3] ESTABLISHMENT AND CHARACTERISTICS OF A GASTRIC-CANCER CELL-LINE (HUGC-OOHIRA) PRODUCING HIGH-LEVELS OF G-CSF, GM-CSF, AND IL-6 - THE PRESENCE OF AUTOCRINE GROWTH-CONTROL BY G-CSF
    BABA, M
    HASEGAWA, H
    NAKAYABU, M
    SHIMIZU, N
    SUZUKI, S
    KAMADA, N
    TANI, K
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 1995, 49 (03) : 207 - 215
  • [4] INVITRO AND INVIVO ACTIVATION OF ENDOTHELIAL-CELLS BY COLONY-STIMULATING FACTORS
    BUSSOLINO, F
    ZICHE, M
    WANG, JM
    ALESSI, D
    MORBIDELLI, L
    CREMONA, O
    BOSIA, A
    MARCHISIO, PC
    MANTOVANI, A
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) : 986 - 995
  • [5] Expression and activation of epidermal growth factor receptors in meningiomas
    Carroll, RS
    Black, PM
    Zhang, JP
    Kirsch, M
    Percec, I
    Lau, N
    Guha, A
    [J]. JOURNAL OF NEUROSURGERY, 1997, 87 (02) : 315 - 323
  • [6] HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR IS A GROWTH-FACTOR ACTIVE ON A VARIETY OF CELL-TYPES OF NONHEMOPOIETIC ORIGIN
    DEDHAR, S
    GABOURY, L
    GALLOWAY, P
    EAVES, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 9253 - 9257
  • [7] DEMETRI GD, 1991, BLOOD, V78, P2791
  • [8] DETTA A, 1993, NEUROSURGERY, V33, P1065
  • [9] FOULKE RS, 1990, CANCER RES, V50, P6264
  • [10] POSTOPERATIVE IRRADIATION FOR SUBTOTALLY RESECTED MENINGIOMAS - A RETROSPECTIVE ANALYSIS OF 140 PATIENTS TREATED FROM 1967 TO 1990
    GOLDSMITH, BJ
    WARA, WM
    WILSON, CB
    LARSON, DA
    [J]. JOURNAL OF NEUROSURGERY, 1994, 80 (02) : 195 - 201