Butyrylcholinesterase and cognitive function

被引：27

作者：

Darvesh, S

MacKnight, C

Rockwood, K

机构：

[1] Dalhousie Univ, Dept Med, Div Neurol, Halifax, NS, Canada

[2] Dalhousie Univ, Div Geriatr Med, Halifax, NS, Canada

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2001年 / 13卷 / 04期

关键词：

cholinesterase; ethopropazine; Alzheimer;

D O I：

10.1017/S1041610201007876

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor. We suggest that, because neurons expressing BuChE may be involved in cognition, there is merit to further evaluation of selective BuChE inhibitors in treating cognitive dysfunction.

引用

页码：461 / 464

页数：4

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