Assignment of the 13C and 15N NMR spectra of the antitumour antibiotic streptonigrin

被引：6

作者：

Anderberg, PI ^{[1
]}

Luck, IJ ^{[1
]}

Harding, MM ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem F11, Sydney, NSW 2006, Australia

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2002年 / 40卷 / 04期

关键词：

NMR; C-13; N-15; streptonigrin; aminoquinone; 2,2 '-bipyridyl; metal complex;

D O I：

10.1002/mrc.997

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by N-15 (HSQC, HMBC) and C-13 (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：313 / 315

页数：3

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