Vaccines against mucosal infections

被引:113
作者
Holmgren, Jan [1 ]
Svennerholm, Ann-Mari
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Vaccine Res Inst GUVAX, Gothenburg, Sweden
关键词
VI-CAPSULAR POLYSACCHARIDE; INACTIVATED POLIOVIRUS VACCINE; HUMAN ROTAVIRUS VACCINE; ORAL CHOLERA VACCINES; TYPHOID-FEVER; SALMONELLA-TYPHI; VIBRIOCIDAL ANTIBODY; SEASONAL INFLUENZA; CONJUGATE VACCINE; EFFICACY TRIAL;
D O I
10.1016/j.coi.2012.03.014
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There remains a great need to develop vaccines against many of the pathogens that infect mucosal tissues or have a mucosal port of entry. Parenteral vaccination may protect in some instances, but usually a mucosal vaccination route is necessary. Mucosal vaccines also have logistic advantages over injectable vaccines by being easier to administer, having less risk of transmitting infections and potentially being easier to manufacture. Still, however, only relatively few vaccines for human use are available: oral vaccines against cholera, typhoid, polio, and rotavirus, and a nasal vaccine against influenza. For polio, typhoid and influenza, in which the pathogens reach the blood stream, there is also an injectable vaccine alternative. A problem with available oral live vaccines is their reduced immunogenicity when used in developing countries; for instance, the efficacy of rotavirus vaccines correlates closely with the national per capita income. Research is needed to define the impact of factors such as malnutrition, aberrant intestinal microflora, concomitant infections, and preexisting immunity as well as of host genetic factors on the immunogenicity of these vaccines.
引用
收藏
页码:343 / 353
页数:11
相关论文
共 78 条
[1]   PREVENTION OF TYPHOID-FEVER IN NEPAL WITH THE VI CAPSULAR POLYSACCHARIDE OF SALMONELLA-TYPHI - A PRELIMINARY-REPORT [J].
ACHARYA, IL ;
LOWE, CU ;
THAPA, R ;
GURUBACHARYA, VL ;
SHRESTHA, MB ;
CADOZ, M ;
SCHULZ, D ;
ARMAND, J ;
BRYLA, DA ;
TROLLFORS, B ;
CRAMTON, T ;
SCHNEERSON, R ;
ROBBINS, JB .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (18) :1101-1104
[2]   Enhanced immunogenicity of an oral inactivated cholera vaccine in infants in Bangladesh obtained by zinc supplementation and by temporary withholding breast-feeding [J].
Ahmed, Tanvir ;
Svennerholm, Ann-Mari ;
Al Tarique, Abdullah ;
Sultana, Gazi N. N. ;
Qadri, Firdausi .
VACCINE, 2009, 27 (09) :1433-1439
[3]   Supplementation with zinc, but not vitamin A, improves seroconversion to vibriocidal antibody in children given an oral cholera vaccine [J].
Albert, MJ ;
Qadri, F ;
Wahed, MA ;
Ahmed, T ;
Rahman, ASMH ;
Ahmed, F ;
Bhuiyan, NA ;
Zaman, K ;
Baqui, AH ;
Clemens, JD ;
Black, RE .
JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (06) :909-913
[4]   Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis [J].
Ali, M ;
Emch, M ;
von Seidlein, L ;
Yunus, M ;
Sack, DA ;
Rao, M ;
Holmgren, J ;
Clemens, JD .
LANCET, 2005, 366 (9479) :44-49
[5]   Use of Oral Cholera Vaccines in an Outbreak in Vietnam: A Case Control Study [J].
Dang Duc Anh ;
Lopez, Anna Lena ;
Vu Dinh Thiem ;
Grahek, Shannon L. ;
Tran Nhu Duong ;
Park, Jin Kyung ;
Kwon, Hye Jung ;
Favorov, Michael ;
Nguyen Tran Hien ;
Clemens, John D. .
PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (01)
[6]   Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial [J].
Armah, George E. ;
Sow, Samba O. ;
Breiman, Robert F. ;
Dallas, Michael J. ;
Tapia, Milagritos D. ;
Feikin, Daniel R. ;
Binka, Fred N. ;
Steele, A. Duncan ;
Laserson, Kayla F. ;
Ansah, Nana A. ;
Levine, Myron M. ;
Lewis, Kristen ;
Coia, Michele L. ;
Attah-Poku, Margaret ;
Ojwando, Joel ;
Rivers, Stephen B. ;
Victor, John C. ;
Nyambane, Geoffrey ;
Hodgson, Abraham ;
Schoedel, Florian ;
Ciarlet, Max ;
Neuzil, Kathleen M. .
LANCET, 2010, 376 (9741) :606-614
[7]   Global, regional, and national causes of child mortality in 2008: a systematic analysis [J].
Black, Robert E. ;
Cousens, Simon ;
Johnson, Hope L. ;
Lawn, Joy E. ;
Rudan, Igor ;
Bassani, Diego G. ;
Jha, Prabhat ;
Campbell, Harry ;
Walker, Christa Fischer ;
Cibulskis, Richard ;
Eisele, Thomas ;
Liu, Li ;
Mathers, Colin .
LANCET, 2010, 375 (9730) :1969-1987
[8]   World wide experience with inactivated poliovirus vaccine [J].
Bonnet, Marie-Claude ;
Dutta, Anil .
VACCINE, 2008, 26 (39) :4978-4983
[9]   Bacteremic typhoid fever in children in an urban slum, Bangladesh [J].
Brooks, WA ;
Hossain, A ;
Goswami, D ;
Sharmeen, AT ;
Nahar, K ;
Alam, K ;
Ahmed, N ;
Naheed, A ;
Nair, GB ;
Luby, S ;
Breiman, RF .
EMERGING INFECTIOUS DISEASES, 2005, 11 (02) :326-329
[10]   Randomized controlled study of fractional doses of inactivated poliovirus vaccine administered intradermally with a needle in the Philippines [J].
Cadorna-Carlos, Josefina ;
Vidor, Emmanuel ;
Bonnet, Marie-Claude .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2012, 16 (02) :E110-E116