Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents

被引：121

作者：

Hellmann, MA ^{[1
]}

Panet, H ^{[1
]}

Barhum, Y ^{[1
]}

Melamed, E ^{[1
]}

Offen, D ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Neurosci Lab, Felsenstein Med Res Ctr,Dept Neurol,Rabin Med Ctr, IL-49100 Petah Tiqwa, Israel

来源：

NEUROSCIENCE LETTERS | 2006年 / 395卷 / 02期

关键词：

bone marrow stem cells; Parkinson's disease; 6-hydroxydopamine;

D O I：

10.1016/j.neulet.2005.10.097

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. Attempted replacement of these neurons by stem cells has proved inconclusive. Bone marrow mesenchymal stem cells (MSC) are multipotent, differentiating into a variety of cells, including neuron-like cells. We used the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease to assess migration and differentiation of transplanted MSC. We found in rodents that transplanted MSC survive better in the 6-OHDA-induced damaged hemisphere compared to the unlesioned side. Moreover, contralaterally engrafted MSC migrated through the corpus callosum to populate the striatum, thalamic nuclei and substantia nigra of the 6-OHDA-lesioned hemisphere. In conclusion, we demonstrate that 6-OHDA-induced damage increases the viability of transplanted MSC and attracts these cells from the opposite hemisphere. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：124 / 128

页数：5

共 21 条

[1] Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].