Targeting nitric oxide to cancer cells:: Cytotoxicity studies of glyco-S-nitrosothiols

被引：46

作者：

Hou, YC

Wang, JQ

Andreana, PR

Cantauria, G

Tarasia, S

Sharp, L

Braunschweiger, PG ^{[1
]}

Wang, PG

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48201 USA

[2] Univ Miami, Dept Radiat Oncol, Miami, FL 33136 USA

[3] Univ Miami, Dept Obstet & Gynecol, Miami, FL 33136 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(99)00363-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glyco-S-nitrosothiols, fructose-2-SNAP and glucose-2-SNAP, were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2255 / 2258

页数：4

共 34 条

[1] Developmental differences determine larval susceptibility to nitric oxide-mediated killing in a murine model of vaccination against Schistosoma mansoni [J].

Ahmed, SF ;

Oswald, IP ;

Caspar, P ;

Hieny, S ;

Keefer, L ;

Sher, A ;

James, SL .

INFECTION AND IMMUNITY, 1997, 65 (01) :219-226

[2]

Bechman JS, 1990, P NATL ACAD SCI USA, V87, P1620

[3] PATHOLOGICAL IMPLICATIONS OF NITRIC-OXIDE, SUPEROXIDE AND PEROXYNITRITE FORMATION [J].

BECKMAN, JS ;

CROW, JP .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1993, 21 (02) :330-334

[4]

Beckman JS., 1996, PHYSIOLOGICAL PATHOL, P1

[5]

BELL GI, 1993, J BIOL CHEM, V268, P19161

[6]

BROWN RS, 1993, CANCER, V72, P2979, DOI 10.1002/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO

[7]

2-X

[8] Nitric oxide enhancement of melphalan-induced cytotoxicity [J].

Cook, JA ;

Krishna, MC ;

Pacelli, R ;

DeGraff, W ;

Liebmann, J ;

Mitchell, JB ;

Russo, A ;

Wink, DA .

BRITISH JOURNAL OF CANCER, 1997, 76 (03) :325-334

[9] The chemistry and tumoricidal activity of nitric oxide hydrogen peroxide and the implications to cell resistance susceptibility [J].

FariasEisner, R ;

Chaudhuri, G ;

Aeberhard, E ;

Fukuto, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (11) :6144-6151

[10] UNUSUALLY STABLE THIONITRITE FROM N-ACETYL-D,L-PENICILLAMINE - X-RAY CRYSTAL AND MOLECULAR-STRUCTURE OF 2-(ACETYLAMINO)-2-CARBOXY-1,1-DIMETHYLETHYL THIONITRITE [J].

FIELD, L ;

DILTS, RV ;

RAVICHANDRAN, R ;

LENHERT, PG ;

CARNAHAN, GE .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (06) :249-250

← 1 2 3 4 →