Increased level of β-amyloid in the brain of bulbectomized mice

被引：66

作者：

Aleksandrova, IY

Kuvichkin, VV

Kashparov, IA

Medvinskaya, NI

Nesterova, IV

Lunin, SM

Samokhin, AN

Bobkova, NV ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Russia

[2] Russian Acad Sci, Inst Prot, Pushchino 142290, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2004年 / 69卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

sporadic Alzheimer's disease; animal models of human diseases; bulbectomy; beta-amyloid; spatial memory;

D O I：

10.1023/B:BIRY.0000018948.04559.ab

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six weeks after bilateral olfactory bulbectomy, a peptide with molecular weight of 4 kD was revealed in extracts of the neocortex and hippocampus from mice. Using monoclonal antibodies 4G8, this peptide was identified as beta-amyloid. Its level was significantly higher in the bulbectomized animals than in sham-operated mice. The bulbectomized mice displayed sharp impairment in spatial memory when tested in the Morris water maze. The results suggest that bulbectomy initiates in the brain a pathological process similar to human Alzheimer's disease in location, biochemistry, and behavioral manifestations.

引用

页码：176 / 180

页数：5

共 23 条

[1]

Banati Richard B., 1995, P1027

[2]

Bobkova N.V., 2001, B EKSP BIOL MED, V131, P507, DOI [10.1023/A:1017907511482, DOI 10.1023/A:1017907511482]

[3]

BOBKOVA NV, 1998, P ANN M SOC NEUR, V24, P438

[4]

BOBKOVA NV, 2003, MORFOLOGIYA, V4, P429