Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85

被引:36
作者
Borst, SE
Vincent, KR
Lowenthal, DT
Braith, RW
机构
[1] VA Med Ctr, Ctr Geriatr Res Educ & Clin, Gainesville, FL USA
[2] Univ Florida, Dept Exercise & Sport Sci, Gainesville, FL USA
[3] Univ Florida, Dept Med, Gainesville, FL USA
[4] Univ Florida, Dept Pharmacol, Gainesville, FL 32610 USA
关键词
training volume; strength training; weight training;
D O I
10.1046/j.1532-5415.2002.50215.x
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
OBJECTIVES: We have reported that resistance training (RT) elevates insulin-like growth factor (IGF-I) in healthy young adults. Our goals were to determine whether RT produces a similar effect in the healthy older persons and to determine the effects of low- versus high-intensity RT on hormonal status. SETTING: Center for Exercise Science., University of Florida, Gainesville. PARTICIPANTS: Sixty-two men and women (mean age 68.1). INTERVENTION: A 6-month, 3-day/week program of low-intensity RT (LEX), high-intensity RT (HEX), or no exercise (CON). MEASUREMENTS: Before and after training, blood was drawn for hormone analysis. IGF-I, IGF binding protein-1 (IGFBP-1), and IGFBP-3 were measured at rest. Testosterone and cortisol were measured at rest and immediately after exercise. RESULTS: RT caused significant increases in I-repetition maximum (1RM) strength and peak oxygen consumption (V0(2peak)), which we have reported separately. Currently, we report that RT had no effect on the r.-sting serum concentrations of IGF-1, IGFBP-1, IGFBP-3, testosterone, or cortisol. Acute resistance exercise caused no change in circulating testosterone in men or women but did cause a significant elevation of cortisol in the HEX group. This increase in cortisol was blunted as a result of training. CONCLUSIONS: We conclude that the increases in strength and endurance caused by RT were not mediated by, increases in circulating IGF-1, IGFBPs, or testosterone.
引用
收藏
页码:884 / 888
页数:5
相关论文
共 23 条
[1]   Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function [J].
Barton-Davis, ER ;
Shoturma, DI ;
Musaro, A ;
Rosenthal, N ;
Sweeney, HL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15603-15607
[2]   Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency - A randomized, placebo-controlled trial [J].
Baum, HBA ;
Biller, BMK ;
Finkelstein, JS ;
Cannistraro, KB ;
Oppenheim, DS ;
Schoenfeld, AD ;
Michel, TH ;
Wittink, H ;
Klibanski, A .
ANNALS OF INTERNAL MEDICINE, 1996, 125 (11) :883-+
[3]  
Bermon S, 1999, ACTA PHYSIOL SCAND, V165, P51
[4]  
Borst SE, 2001, MED SCI SPORT EXER, V33, P648
[5]   The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action [J].
CollettSolberg, PF ;
Cohen, P .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1996, 25 (03) :591-&
[6]   INDUCTION OF IMMUNOREACTIVE SOMATOMEDIN-C IN HUMAN-SERUM BY GROWTH-HORMONE - DOSE-RESPONSE RELATIONSHIPS AND EFFECT ON CHROMATOGRAPHIC PROFILES [J].
COPELAND, KC ;
UNDERWOOD, LE ;
VANWYK, JJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 50 (04) :690-697
[7]   Hormonal regulation of skeletal muscle hypertrophy in rats: The testosterone to cortisol ratio [J].
Crowley, MA ;
Matt, KS .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 1996, 73 (1-2) :66-72
[8]   ACTIVATION OF INSULIN-LIKE GROWTH-FACTOR GENE-EXPRESSION DURING WORK-INDUCED SKELETAL-MUSCLE GROWTH [J].
DEVOL, DL ;
ROTWEIN, P ;
SADOW, JL ;
NOVAKOFSKI, J ;
BECHTEL, PJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (01) :E89-E95
[9]   Modeling of circadian testosterone in healthy men and hypogonadal men [J].
Gupta, SK ;
Lindemulder, EA ;
Sathyan, G .
JOURNAL OF CLINICAL PHARMACOLOGY, 2000, 40 (07) :731-738
[10]   Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: The framingham heart study. [J].
Harris, TB ;
Kiel, D ;
Roubenoff, R ;
Langlois, J ;
Hannan, M ;
Havlik, R ;
Wilson, P .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1997, 45 (02) :133-139