A variant of variola virus, characterized by changes in polypeptide and endonuclease profiles

被引：4

作者：

Dumbell, KR

Harper, L

Buchan, A

Douglass, NJ

Bedson, HS

机构：

[1] Univ London, St Marys Hosp, Sch Med, London WC1E 7HU, England

[2] PHLS Ctr Appl Microbiol & Res, Salisbury, Wilts, England

[3] Univ Cape Town, Dept Med Microbiol, ZA-7700 Rondebosch, South Africa

[4] Univ Birmingham, Dept Med Microbiol, Birmingham B15 2TT, W Midlands, England

来源：

EPIDEMIOLOGY AND INFECTION | 1999年 / 122卷 / 02期

关键词：

D O I：

10.1017/S0950268899002150

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A variant of variola virus is described which produces a late polypeptide of 25 kDa instead of one of 27 kDa and which has an additional endonuclease cleavage site for SalI in the viral DNA. These markers were shown to be genetically independent and to characterize 14 of the 48 variola strains which were examined. The variant strains were isolated from smallpox outbreaks originating in or from Pakistan between 1961 and 1974 and also from two cases at a Mission Hospital in Vellore, India in 1964, No variant strains were found among 9 other isolates from cases of variola major occurring in other parts of India or in Bangladesh, nor among 4 isolates from Indonesia, 15 from Africa or 6 isolates of variola minor.

引用

页码：287 / 290

页数：4

共 12 条

[1] NUCLEOTIDE-SEQUENCE OF 21.8 KBP OF VARIOLA MAJOR VIRUS-STRAIN HARVEY AND COMPARISON WITH VACCINIA VIRUS [J].