AMPA-Induced suppression of oligodendroglial gene expression in neonatal rat brain

被引：10

作者：

Xu, HY

Barks, JDE

Liu, YQ

Silverstein, FS

机构：

[1] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2001年 / 132卷 / 02期

关键词：

excitotoxicity; glia; proteolipid proteins; myelin basic protein;

D O I：

10.1016/S0165-3806(01)00306-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oligodendroglia are susceptible to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) -mediated excitotoxicity. We hypothesized that analysis of oligodendroglial gene expression would provide a sensitive indicator of acute excitotoxic oligodendroglial injury in the immature brain. AMPA (2 nmol) was injected intracerebroventricularly in 7-day-old rats. Proteolipid protein and myelin basic protein encoding mRNAs were evaluated 24-48 h later by semi-quantitative reverse transcription-polymerase chain reaction assays. AMPA markedly suppressed brain tissue content of oligodendroglial mRNAs. (C) 2001 Elsevier Science BY. All rights reserved.

引用

页码：175 / 178

页数：4

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[2]

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