Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture

被引：71

作者：

Riggle, FJ

Andrutis, KA

Chen, X

Tzipori, SR

Kumamoto, CA

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

[2] Tufts Univ, Sch Vet Med, Div Infect Dis, North Grafton, MA 01536 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 07期

关键词：

D O I：

10.1128/IAI.67.7.3649-3652.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A Candida albicans efg1 cph1 double mutant is nonfilamentous under standard laboratory conditions and avirulent in mice. However, this mutant produced filaments in the tongues of immunosuppressed gnotobiotic piglets and when embedded in agar, demonstrating that an Efg1p- and Cph1p-independent pathway for promotion of filamentous growth exists.

引用

页码：3649 / 3652

页数：4

共 12 条

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