CD43 has a functional NLS, interacts with β-catenin, and affects gene expression

被引：24

作者：

Andersson, CX

Fernandez-Rodriguez, J

Laos, S

Sikut, R

Sikut, A

Baeckström, D

Hansson, GC

机构：

[1] Univ Gottingen, Dept Biochem Med, S-41390 Gothenburg, Sweden

[2] Univ Tartu, Inst Mol & Cell Biol, EE-51010 Tartu, Estonia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 316卷 / 01期

关键词：

CD43; beta-catenin; mucin; nucleus; NLS;

D O I：

10.1016/j.bbrc.2004.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the beta-catenin target genes c-MYC and CyclinD1. The present results suggest that CD43 can be involved in nuclear signaling and via beta-catenin interaction be involved in cell proliferation. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：12 / 17

页数：6