Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues

被引:26
作者
Lundquist, JT [1 ]
Dix, TA [1 ]
机构
[1] Med Univ S Carolina, Dept Pharmaceut Sci, Charleston, SC 29425 USA
关键词
D O I
10.1016/S0960-894X(99)00420-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Cyclic analogues of neurotensin (NT) C-terminal fragments NT(8-13) and NT(9-13) were produced via intramolecular nucleophilic substitution of the Tyr(11) phenoxide anion on a 6-bromohexanoyl side chain substituted at position 8 or 9 and tested for NT receptor binding affinity. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2579 / 2582
页数:4
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