Binding of intronic miRNAs to the mRNAs of host genes encoding intronic miRNAs and proteins that participate in tumourigenesis

被引：27

作者：

Berillo, O. ^{[1
]}

Regnier, M. ^{[2
]}

Ivashchenko, A. ^{[1
]}

机构：

[1] Al Farabi Kazakh Natl Univ, Natl Nanotechnol Lab, Alma Ata, Kazakhstan

[2] INRIA LIX Team AMIB, F-91120 Palaiseau, France

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2013年 / 43卷 / 10期

关键词：

Binding site; Cancer; Host gene; Intronic miRNA; mRNA; POTENTIAL BIOMARKERS; MICRORNA EXPRESSION; MIR-155; EXPRESSION; INTRAGENIC MIRNAS; EARLY-DIAGNOSIS; CANCER; REVEALS; IDENTIFICATION; TRANSCRIPTION; MIR-205;

D O I：

10.1016/j.compbiomed.2013.07.011

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

In this study, we examined 615 host genes encoding 915 in-miRNAs as possible targets for interactions with all in-miRNAs. Host genes whose proteins are involved in esophageal, gastric, small bowel, colorectal, and breast cancer development were studied. Unique in-miRNA binding sites with a significance of p < 0.0005 were found in the 5'UTRs, CDSs, and 3'UTRs of the host genes encoding proteins that are key participants in tumourigenesis. These data shed light on the interactions between miRNAs and mRNAs and on the role of candidate proteins in cancer. Therefore, our findings have potential application in the development of diagnostic and treatment methods. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1374 / 1381

页数：8

共 49 条

[1]

An intronic microRNA silences genes that are functionally antagonistic to its host gene [J].