An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus

被引：99

作者：

Yao, Yanfeng ^{[1
,2
]}

Bao, Linlin ^{[1
,2
]}

Deng, Wei ^{[1
,2
]}

Xu, Lili ^{[1
,2
]}

Li, Fengdi ^{[1
,2
]}

Lv, Qi ^{[1
,2
]}

Yu, Pin ^{[1
,2
]}

Chen, Ting ^{[1
,2
]}

Xu, Yanfeng ^{[1
,2
]}

Zhu, Hua ^{[1
,2
]}

Yuan, Jing ^{[1
,2
]}

Gu, Songzhi ^{[1
,2
]}

Wei, Qiang ^{[1
,2
]}

Chen, Honglin ^{[3
,4
]}

Yuen, Kwok-Yung ^{[3
,4
]}

Qin, Chuan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Minist Hlth, Inst Lab Anim Sci, Key Lab Human Dis Comparat Med, Beijing 100730, Peoples R China

[2] Peking Union Med Coll, Comparat Med Ctr, Beijing 100021, Peoples R China

[3] Univ Hong Kong, Dept Microbiol, State Key Lab Emerging Infect Dis, Pokfulam, Hong Kong, Peoples R China

[4] Univ Hong Kong, Res Ctr Infect & Immunol, Pokfulam, Hong Kong, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 02期

关键词：

animal model; coronavirus; MERS; pathology; rhesus monkey; RESPIRATORY SYNDROME CORONAVIRUS; CLINICAL-FEATURES; BATS; 2C; PNEUMONIA; VIRUSES; DISEASE;

D O I：

10.1093/infdis/jit590

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.

引用

页码：236 / 242

页数：7

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