Multi-component reactions and evolutionary chemistry

被引：333

作者：

Weber, L ^{[1
]}

机构：

[1] Morphochem, D-81379 Munich, Germany

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1359-6446(02)00010-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.

引用

页码：143 / 147

页数：5

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