Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group

被引：415

作者：

Kossoff, Eric H. ^{[1
]}

Zupec-Kania, Beth A. ^{[2
]}

Amark, Per E. ^{[3
]}

Ballaban-Gil, Karen R. ^{[4
]}

Bergqvist, A. G. Christina ^{[5
]}

Blackford, Robyn ^{[6
]}

Buchhalter, Jeffrey R. ^{[7
]}

Caraballo, Roberto H. ^{[8
]}

Cross, J. Helen ^{[9
,10
]}

Dahlin, Maria G. ^{[3
]}

Donner, Elizabeth J. ^{[11
]}

Klepper, Joerg ^{[12
]}

Jehle, Rana S. ^{[4
]}

Kim, Heung Dong ^{[13
]}

Liu, Y. M. Christiana ^{[11
]}

Nation, Judy ^{[14
]}

Nordli, Douglas R., Jr. ^{[6
]}

Pfeifer, Heidi H. ^{[15
]}

Rho, Jong M. ^{[16
]}

Stafstrom, Carl E. ^{[17
]}

Thiele, Elizabeth A. ^{[15
]}

Turner, Zahava ^{[1
]}

Wirrell, Elaine C. ^{[18
]}

Wheless, James W. ^{[19
]}

Veggiotti, Pierangelo ^{[20
]}

Vining, Eileen P. G. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Baltimore, MD 21205 USA

[2] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA

[3] Karolinska Hosp, S-10401 Stockholm, Sweden

[4] Montefiore Med Ctr, Bronx, NY 10467 USA

[5] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[6] Childrens Mem Hosp, Chicago, IL 60614 USA

[7] Phoenix Childrens Hosp, Phoenix, AZ USA

[8] Hosp Pediat Prof Dr Juan P Garrahan, Buenos Aires, DF, Argentina

[9] Great Ormond St Hosp Sick Children, London WC1N 3JH, England

[10] Inst Child Hlth, London, England

[11] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[12] Childrens Hosp, Aschaffenburg, Germany

[13] Severance Childrens Hosp, Seoul, South Korea

[14] Royal Childrens Hosp, Melbourne, Vic, Australia

[15] Massachusetts Gen Hosp, Boston, MA 02114 USA

[16] Barrow Neurol Inst, Phoenix, AZ 85013 USA

[17] Univ Wisconsin, Madison, WI USA

[18] Mayo Clin, Rochester, MN USA

[19] St Jude Childrens Res Hosp, Lebonheur Childrens Med Ctr, Memphis, TN 38101 USA

[20] Univ Pavia, I-27100 Pavia, Italy

来源：

EPILEPSIA | 2009年 / 50卷 / 02期

关键词：

Children; Consensus; Diet; Epilepsy; Ketogenic; MODIFIED ATKINS DIET; MYOCLONIC-ASTATIC EPILEPSY; INTRACTABLE EPILEPSY; PEDIATRIC EPILEPSY; CHILDHOOD EPILEPSY; RISK-FACTORS; ANTIEPILEPTIC DRUGS; TUBEROUS-SCLEROSIS; INFANTILE SPASMS; DRAVET SYNDROME;

D O I：

10.1111/j.1528-1167.2008.01765.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The ketogenic diet (KD) is an established, effective nonpharmacologic treatment for intractable childhood epilepsy. The KD is provided differently throughout the world, with occasionally significant variations in its administration. There exists a need for more standardized protocols and management recommendations for clinical and research use. In December 2006, The Charlie Foundation commissioned a panel comprised of 26 pediatric epileptologists and dietitians from nine countries with particular expertise using the KD. This group was created in order to create a consensus statement regarding the clinical management of the KD. Subsequently endorsed by the Practice Committee of the Child Neurology Society, this resultant manuscript addresses issues such as patient selection, pre-KD counseling and evaluation, specific dietary therapy selection, implementation, supplementation, follow-up management, adverse event monitoring, and eventual KD discontinuation. This paper highlights recommendations based on best evidence, including areas of agreement and controversy, unanswered questions, and future research.

引用

页码：304 / 317

页数：14

共 84 条

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