PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals

被引：99

作者：

Burza, Maria Antonella ^{[1
,2
]}

Pirazzi, Carlo ^{[1
,2
]}

Maglio, Cristina ^{[1
,2
]}

Sjoholm, Kajsa ^{[1
,2
]}

Mancina, Rosellina Margherita ^{[1
,2
,4
]}

Svensson, Per-Arne ^{[1
,2
]}

Jacobson, Peter ^{[1
,2
]}

Adiels, Martin ^{[1
,2
]}

Baroni, Marco Giorgio ^{[3
]}

Boren, Jan ^{[1
,2
]}

Corradini, Stefano Ginanni ^{[5
]}

Montalcini, Tiziana ^{[4
]}

Sjostrom, Lars ^{[1
,2
]}

Carlsson, Lena Mariana Susann ^{[1
,2
]}

Romeo, Stefano ^{[1
,2
,4
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Ctr Cardiovasc & Metab Res, Gothenburg, Sweden

[3] Univ Cagliari, Dept Med Sci, I-09124 Cagliari, Italy

[4] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Clin Nutr Unit, Catanzaro, Italy

[5] Univ Roma La Sapienza, Dept Clin Med, Div Gastroenterol, Rome, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2012年 / 44卷 / 12期

基金：

瑞典研究理事会;

关键词：

Liver cancer; Obesity; Patatin-like phospholipase domain-containing 3; Swedish obese subjects study; FATTY LIVER-DISEASE; HISTOLOGICAL SEVERITY; RISK; POLYMORPHISM; SUSCEPTIBILITY; ADIPONUTRIN; MORTALITY; CIRRHOSIS; INDEXES; DAMAGE;

D O I：

10.1016/j.dld.2012.05.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: Obesity is a risk factor for cancer, including hepatocellular carcinoma. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) in individuals with chronic alcohol abuse or hepatic viral infection. In the present study we examined the association between the PNPLA3I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n=4047). Methods: We performed a matched, prospective, controlled, interventional trial, investigating the effect of bariatric surgery (surgery group) compared to conventional treatment (control group) for obesity. Results: A total of 9 events were observed in the 15-year median follow up (5 in the control group and 4 in the surgery group). A significantly higher incidence of hepatocellular carcinoma in PNPLA3 148M allele carriers was found in obese individuals in the control group (log-rank P-value=0.001), but not in the surgery group (log-rank P-value=0.783). Consistently, an increased risk (for each PNPLA3 148M allele, hazard ratio: 5.9; 95% confidence interval 1.5-23.8; P-value=0.013) of developing hepatocellular carcinoma was observed only in the control group. Conclusion: The current study is the first prospective report showing the association of the PNPLA3I148M genetic variant and hepatocellular carcinoma in severely obese individuals. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：1037 / 1041

页数：5

共 29 条

[1]

BROLIN RE, 1987, GASTROENTEROL CLIN N, V16, P317

[2]

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults [J].