Mycophenolate mofetil decreases antibody production after cardiac transplantation

被引：70

作者：

Rose, ML ^{[1
]}

Smith, J

Dureau, G

Keogh, A

Kobashigowa, J

机构：

[1] Harefield Hosp, Imperial Coll Sch Med, Natl Heart & Lung Inst, Harefield UB9 6JH, Middx, England

[2] Hop Lyon, Lyon, France

[3] St Vincents Hosp, Sydney, NSW 2010, Australia

[4] Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2002年 / 21卷 / 02期

关键词：

D O I：

10.1016/S1053-2498(01)00335-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New immunosuppressive drugs are extensively being investigated for their effect on T-cell immunity, with far less being known about their effect on the humoral immune response. In view of the experimental and clinical evidence that humoral immunity contributes to acute and chronic rejection, we investigated post-transplant production of anti-vimentin and anti-HLA antibodies in 86 patients who were part of a worldwide clinical trial for mycophenolate mofetil in cardiac transplantation. The results demonstrate that patients taking MMF instead of azathioprine generated significantly fewer de novo anti-vimentin antibodies.

引用

页码：282 / 285

页数：4

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