N-Acylhomoserine Lactone-Mediated Quorum Sensing: A Twist in the Tail and a Blow for Host Immunity

被引：66

作者：

Cooley, Margaret ^{[2
,3
]}

Chhabra, Siri Ram ^{[1
]}

Williams, Paul ^{[1
]}

机构：

[1] Univ Nottingham, Ctr Biomol Sci, Inst Infect Immun & Inflammat, Nottingham NG7 2RD, England

[2] Univ Tasmania, Menzies Res Inst, Hobart, Tas 7001, Australia

[3] Univ Tasmania, Sch Med, Hobart, Tas 7001, Australia

来源：

CHEMISTRY & BIOLOGY | 2008年 / 15卷 / 11期

关键词：

D O I：

10.1016/j.chembiol.2008.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Communication through quorum sensing (OS) enables bacterial populations to coordinate their behavior. Recent work on N-acylhomoserine lactone-mediated QS has revealed that some soil bacteria exploit host-derived substrates to generate an alternative N-substituted homoserine lactone. New light has also been shed on the mechanism by which N-(3-oxo-dodecanoyl)-L-homoserine lactone modulates host inflammatory signaling pathways to promote bacterial survival.

引用

页码：1141 / 1147

页数：7

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