Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases

被引：4

作者：

Zhou, Jianda ^{[1
]}

Liu, Jinyan ^{[1
]}

Luo, Chengqun ^{[1
]}

Hu, Feng ^{[1
]}

Liu, Rui ^{[1
]}

Chen, Zizi ^{[1
]}

Chen, Yao ^{[1
]}

Xiong, Wu ^{[1
]}

Xie, Jianfei ^{[1
]}

He, Quanyong ^{[1
]}

Yin, Chaoqi ^{[1
]}

Wang, Shaohua ^{[1
]}

Zhang, Yanwen ^{[1
]}

Zeng, Sainan ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2013年 / 6卷 / 01期

关键词：

burn; multiple intracranial hemorrhages; platelet; coagulation abnormalities; complication; INFLAMMATION; COAGULATION; INJURY; TISSUE;

D O I：

10.3892/etm.2013.1081

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The aim of this study was to explore the etiology and diagnosis of multiple intracranial hemorrhages (ICHs) following severe burns, with a retrospective review of 16 cases of severe burns further complicated by multiple ICHs. Using cranial CT scans of the brains, we identified that all patients presented with low platelet counts and coagulation abnormalities prior to intracranial hemorrhaging. Following conventional treatment and various supporting treatments, five cases succumbed following a progressive reduction in blood platelet levels and the ICHs were cured in 11 cases following the restoration of normal platelet levels. We conclude that low platelet counts and coagulation abnormalities may cause multiple ICHs following severe burns and early diagnosis and treatment is the key to successful treatment.

引用

收藏

页码：223 / 227

页数：5

相关论文

共 17 条

[1]

Stroke after burn [J].

Cho, Soo-Jin ;

Minn, Yang-Ki ;

Kwon, Ki-Han .

CEREBROVASCULAR DISEASES, 2007, 24 (2-3) :261-263

[2]

Upper airway mucus deposition in lung tissue of burn trauma victims [J].

Cox, Robert A. ;

Mlcak, Ron P. ;

Chinkes, David L. ;

Jacob, Sam ;

Enkhbaatar, Perenlei ;

Jaso, Jesse ;

Parish, Lauren P. ;

Traber, Daniel L. ;

Jeschke, Marc G. ;

Herndon, David N. ;

Hawkins, Hal K. .

SHOCK, 2008, 29 (03) :356-361

[3]

Pathogenic alteration in severe burn wounds [J].

Fu, Yang ;

Xie, Bing ;

Ben, DaoFeng ;

Lv, KaiYang ;

Zhu, ShiHui ;

Lu, Wei ;

Tang, HongTai ;

Cheng, DaSheng ;

Ma, Bing ;

Wang, GuangYi ;

Xiao, ShiChu ;

Wang, GuangQing ;

Xia, ZhaoFan .

BURNS, 2012, 38 (01) :90-94

[4]

Abnormal Insulin Sensitivity Persists up to Three Years in Pediatric Patients Post-Burn [J].

Gauglitz, Gerd G. ;

Herndon, David N. ;

Kulp, Gabriela A. ;

Meyer, Walter J., III ;

Jeschke, Marc G. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (05) :1656-1664

[5]

Persistence of muscle catabolism after severe burn [J].

Hart, DW ;

Wolf, SE ;

Mlcak, R ;

Chinkes, DL ;

Ramzy, PI ;

Obeng, MK ;

Ferrando, AA ;

Wolfe, RR ;

Herndon, DN .

SURGERY, 2000, 128 (02) :312-319

[6]

Leukocyte activation: The link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris [J].

Huisse, Marie-Genevieve ;

Pease, Sebastian ;

Hurtado-Nedelec, Margarita ;

Arnaud, Bertrand ;

Malaquin, Cecile ;

Wolff, Michel ;

Gougerot-Pocidalo, Marie-Anne ;

Kermarrec, Nathalie ;

Bezeaud, Annie ;

Guillin, Marie-Claude ;

Paoletti, Xavier ;

Chollet-Martin, Sylvie .

CRITICAL CARE MEDICINE, 2008, 36 (08) :2288-2295

[7]

Pathophysiologic response to severe burn injury [J].

Jeschke, Marc G. ;

Chinkes, David L. ;

Finnerty, Celeste C. ;

Kulp, Gabriela ;

Suman, Oscar E. ;

Norbury, William B. ;

Branski, Ludwik K. ;

Gauglitz, Gerd G. ;

Mlcak, Ronald P. ;

Herndon, David N. .

ANNALS OF SURGERY, 2008, 248 (03) :387-400

[8]

Mild traumatic brain injury -: Toward understanding manifestations and treatment [J].

Kushner, D .

ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (15) :1617-1624

[9]

Lee J, 2012, EMERG RADIOL

[10]

Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome [J].

Marshall, JC .

CRITICAL CARE MEDICINE, 2001, 29 (07) :S99-S106