ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data

被引：117

作者：

Buck, MJ

Nobel, AB

Lieb, JD

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Stat, Chapel Hill, NC 27599 USA

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 11期

关键词：

D O I：

10.1186/gb-2005-6-11-r97

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.

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页数：8

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