Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus

被引：38

作者：

Fendt, M ^{[1
]}

机构：

[1] Univ Tubingen, D-72076 Tubingen, Germany

来源：

BRAIN RESEARCH | 1999年 / 833卷 / 01期

关键词：

acoustic startle response; GABA; picrotoxin; prepulse inhibition; rat; schizophrenia; sensorimotor gating; superior colliculus;

D O I：

10.1016/S0006-8993(99)01525-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the effects of local microinjections of the GABA chloride channel blocker Picrotoxin into the superior colliculus (SC) on prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is a useful model for the investigation of the neuronal basis of sensorimotor gating which is deficient in some psychiatric disorders, such as schizophrenia. Blockade of GABA activity within the SC by Picrotoxin injections (leading to a moderate stimulation of the SC) significantly enhanced PPI without affecting the ASR baseline amplitude or the spontaneous motor activity. Based on these results we discuss the role of the SC in a hypothetical neuronal circuit mediating PPI of the ASR. (C) 1999 Elsevier Science B.V. All rights reserved.

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收藏

页码：81 / 85

页数：5

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