Melatonin and the Immune System in Aging

被引：110

作者：

Cardinali, Daniel P. ^{[1
]}

Esquifino, Ana I. ^{[2
]}

Srinivasan, Venkataramanujan ^{[3
]}

Pandi-Perumal, Seithikurippu R. ^{[4
]}

机构：

[1] Univ Buenos Aires, Fac Med, Dept Fisiol, RA-1121 Buenos Aires, DF, Argentina

[2] Univ Complutense, Fac Med, Dept Bioquim & Biol Mol, E-28040 Madrid, Spain

[3] SRM Univ, SRM Med Coll Hosp & Res Ctr, Kattankulathoor, India

[4] Columbia Univ, Coll Phys & Surg, Div Clin Pharmacol & Expt Therapeut, Dept Med, New York, NY USA

来源：

NEUROIMMUNOMODULATION | 2008年 / 15卷 / 4-6期

关键词：

Melatonin; Immunosenescence; Pineal gland; Innate immunity; Humoral immunity; Cellular immunity; Cytokines; Antioxidants; Apoptosis;

D O I：

10.1159/000156470

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. Circulating melatonin decreases with age, and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also stimulates the production of natural killer cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：272 / 278

页数：7

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