Liver sinusoidal endothelial cells and liver regeneration

被引：228

作者：

DeLeve, Laurie D. ^{[1
,2
]}

机构：

[1] Univ So Calif, Keck Sch, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch, USC Res Ctr Liver Dis, Los Angeles, CA 90033 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 05期

关键词：

HEPATOCYTE GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; RAT-LIVER; PARTIAL-HEPATECTOMY; PROGENITOR CELLS; UP-REGULATION; INJURY; ACTIVATION; ANGIOGENESIS; EXPRESSION;

D O I：

10.1172/JCI66025

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase greatly. In contrast, bone marrow progenitor cells of LSECs (BM SPCs), which are rich in HGF, are recruited to the liver after injury. This Review examines liver regeneration from the perspective that BM SPCs that have been recruited to the liver, rather than mature LSECs, drive liver regeneration.

引用

页码：1861 / 1866

页数：6

共 58 条

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DIFFERENCES IN THE LECTIN-BINDING PATTERNS OF THE PERIPORTAL AND PERIVENOUS ENDOTHELIAL DOMAINS IN THE LIVER SINUSOIDS [J].