CD45 and Src-family kinases: and now for something completely different

被引：81

作者：

Ashwell, JD ^{[1
]}

D'Oro, U ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, NIH, Bethesda, MD 20892 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(99)01505-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How does the CD45 tyrosine phosphatase regulate Src-family kinase activity in vivo? Here, Jonathan Ashwell and Ugo D'Oro discuss evidence that, contrary to the widely accepted model, CD45 can actually inhibit the activity of some Src-family kinases by dephosphorylating the positive regulatory tyrosine in the activation loop of the catalytic region.

引用

页码：412 / 416

页数：5

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