A cap for all occasions

被引：31

作者：

Varani, G

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, Hills Road

来源：

STRUCTURE | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1016/S0969-2126(97)00239-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 5' end of each polymerase II transcript is capped by a methylated guanosine triphosphate. The cap earmarks the mRNA for subsequent processing and nucleocytoplasmic transport, protects the mRNA from degradation and promotes efficient initiation of protein synthesis. The recently solved structures of capping enzymes and cap-protein complexes shed light on how the 5' ends of mRNAs are modified, and reveals the mechanisms by which the cap is recognized and how it functions in a diverse range of processes.

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页码：855 / 858

页数：4

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