Synthesis of pyrrolo[2,3-d]pyrimidines that are structurally related to methylated guanosines from tRNA and the nucleoside Q analogs, PreQ(0) and PreQ(1)

被引：9

作者：

Cheng, CS

Hoops, GC

Earl, RA

Townsend, LB

机构：

[1] UNIV MICHIGAN,COLL PHARM,DEPT MED CHEM,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,COLL LITERATURE SCI & ARTS,DEPT CHEM,ANN ARBOR,MI 48109

[3] UNIV UTAH,COLL PHARM,DEPT MED CHEM,SALT LAKE CITY,UT 84112

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 04期

关键词：

D O I：

10.1080/07328319708001355

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The N-3- and N-2-methylated analogs of several 5-substituted 2-amino-7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidin-4-ones were synthesized from 5-cyano-2,4-dichloro-7-(2,3,5-tri-(O>$) over bar under bar>-acetyl-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (10) These compounds are analogs of nucleoside Q that are methylated in a manner similar to some of the naturally occurring methylated guanosines.

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页码：347 / 364

页数：18

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