20-HETE in neovascularization

被引：39

作者：

Chen, Li ^{[1
,2
]}

Ackerman, Rachel ^{[1
]}

Guo, Austin M. ^{[1
,2
]}

机构：

[1] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA

[2] Wuhan Univ, Dept Pharmacol, Sch Med, Wuhan 430071, Peoples R China

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2012年 / 98卷 / 3-4期

关键词：

Neovascularization; Arachidonic acid metabolism; 20-HETE; Endothelial cells; Endothelial progenitor cells; Signaling; ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; POLYCYSTIC KIDNEY-DISEASE; SIGNAL-REGULATED KINASE; MARROW-DERIVED CELLS; FACTOR-KAPPA-B; ARACHIDONIC-ACID; 20-HYDROXYEICOSATETRAENOIC ACID; PROGENITOR CELLS; STEM-CELLS;

D O I：

10.1016/j.prostaglandins.2011.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cytochrome P450 4A/F (CYP4A/F) converts arachidonic acid (AA) to 20-HETE by omega-hydroxylation. The contribution of 20-HETE to the regulation of myogenic response, blood pressure, and mitogenic actions has been well summarized. This review focuses on the emerging role of 20-HETE in physiological and pathological vascularization. 20-HETE has been shown to regulate vascular smooth muscle cells (VSMC) and endothelial cells (EC) by affecting their proliferation, migration, survival, and tube formation. Furthermore, the proliferation, migration, secretion of proangiogenic molecules (such as HIF-1 alpha, VEGF, SDF-1 alpha), and tube formation of endothelial progenitor cells (EPC) are stimulated by 20-HETE. These effects are mediated through c-Src- and EGFR-mediated downstream signaling pathways, including MAPK and PI3K/Akt pathways, eNOS uncoupling, and NOX/ROS system activation. Therefore, the CYP4A/F-20-HETE system may be a therapeutic target for the treatment of abnormal angiogenic diseases. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：63 / 68

页数：6

共 122 条

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