Genomic structure of the EPHA1 receptor tyrosine kinase gene

被引：7

作者：

Owshalimpur, D ^{[1
]}

Kelley, MJ ^{[1
]}

机构：

[1] NCI, Lung Canc Biol Sec, Bethesda, MD 20889 USA

来源：

MOLECULAR AND CELLULAR PROBES | 1999年 / 13卷 / 03期

关键词：

exon; intron; mutation; evolution; genomic structure;

D O I：

10.1006/mcpr.1999.0228

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Some receptor tyrosine kinase genes are mutated in inherited and somatically acquired human cancers. To permit mutational analysis, the complete genomic structure of the human EPHA1 gene on chromosome 7q34 was determined and oligonucleotide pairs were designed to amplify coding regions. The gene contains 18 exons, two more than the related tyrosine kinase, EPHB2. Presumed sequencing errors in the published cDNA sequence of EPHA1 were identified in exons 10 and 11. Availability of this information will facilitate mutational analysis of EPHA1.

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收藏

页码：169 / 173

页数：5

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