cycloSal-Pronucleotides - Design of Chemical Trojan Horses

被引：59

作者：

Meier, Chris ^{[1
]}

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 03期

关键词：

D O I：

10.2174/1389557023406205

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pronucleotides represent a promising alternative to improve the biological activity of nucleoside analogues against different viral diseases. The basic idea is to achieve nucleotide delivery into cells bypassing limitations encountered during the intracellular formation of nucleotides. The cycloSal-concept is one of several pronucleotide systems reported so far. For some nucleoside analogues, the cycloSal-approach improved antiviral potency thus broadening the applicability of nucleosides. The initial design, chemistry, the proof-of-principle and different applications of the cycloSal-strategy will be discussed in this review.

引用

页码：219 / 234

页数：16

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